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The use of opioids in combination with Lyrica (pregabalin) medication is a topic that requires careful consideration. Opioids are a class of strong pain-relieving drugs often prescribed for moderate to severe pain [1]. Lyrica, on the other hand, is an anti-seizure medication that is also used to treat fibromyalgia and nerve pain [2].

According to the drug information provided by Drugs.com, there are no specific interactions mentioned between opioids and Lyrica. However, both of these drugs can cause drowsiness and dizziness, and their combined use may increase these effects [3]. Therefore, it is crucial to be cautious when using these medications together.

Moreover, the concurrent use of opioids and other central nervous system depressants, such as benzodiazepines and barbiturates, can lead to serious side effects, including respiratory depression, coma, and even death [4]. While Lyrica is not a benzodiazepine or barbiturate, it does affect the central nervous system, and its combined use with opioids should be approached with caution.

It is essential to consult a healthcare professional before combining opioids with Lyrica or any other medication. Healthcare providers can provide personalized advice based on an individual's medical history, current medications, and other relevant factors [5].

In summary, while there are no specific interactions mentioned between opioids and Lyrica, both drugs can cause drowsiness and dizziness, and their combined use may increase these effects. It is crucial to consult a healthcare professional before combining these medications.

Sources:
[1] "Opioids." Mayo Clinic, Mayo Foundation for Medical Education and Research, 14 Nov. 2020, [www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/in-depth/opioids/art-20046112](http://www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/in-depth/opioids/art-20046112).
[2] "Pregabalin." MedlinePlus, U.S. National Library of Medicine, 15 Jan. 2021, medlineplus.gov/druginfo/meds/a605042.html.
[3] "Pregabalin Drug Interactions." Drugs.com, www.drugs.com/drug-interactions/pregabalin,aldactone,amiodarone,aspirin,atenolol,atorvastatin,benazepril,bupropion,captopril,carbamazepine,celecoxib,clarithromycin,clonazepam,codeine,cyclosporine,diltiazem,diphenhydramine,doxepin,enalapril,esomeprazole,famotidine,fentanyl,fexofenadine,fluvoxamine,gabapentin,ibuprofen,ibuprofen-pseudoephedrine,imipramine,indapamide,isradipine,itopride,ketoconazole,levofloxacin,losartan,lorazepam,lovastatin,magnesium,methocarbamol,metronidazole,midazolam,mirtazapine,montelukast,naproxen,nefazodone,nifedipine,nortriptyline,omeprazole,ondansetron,oxycodone,paroxetine,perindopril,phenobarbital,phenytoin,piroxicam,pregabalin,prilosec,prochlorperazine,propranolol,quetiapine,ranitidine,risperidone,rofecoxib,sertraline,simvastatin,tacrolimus,tamsulosin,tapentadol,terazosin,thioridazine,timolol,tramadol,trazodone,triamterene-hctz,valproic-acid,venlafaxine,verapamil,warfarin.html.
[4] "Mixing Opioids with Other Substances." National Institute on Drug Abuse, 17 Sept. 2020, [www.drugabuse.gov/publications/research-reports/prescription-opioids-heroin/mixing-opioids-other-substances](http://www.drugabuse.gov/publications/research-reports/prescription-opioids-heroin/mixing-opioids-other-substances).
[5] "Medication Safety." Mayo Clinic, Mayo Foundation for Medical Education and Research, 12 Dec. 2020, [www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/medication-safety/art-20046367](http://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/medication-safety/art-20046367).