See the DrugPatentWatch profile for tigecycline

Based on the information available, there is no specific recorded instance of a fatal overdose directly attributed to Tigecycline. Tigecycline is an antibiotic used to treat various bacterial infections, and its dosage is typically determined by the patient's weight and the type of infection being treated [1].

The maximum recommended dosage of Tigecycline is 50 mg every 12 hours for adults, with an initial dose of 100 mg [2]. The drug's label does not specify a maximum dosage beyond which fatalities have been recorded [3].

It is important to note that overdosing on antibiotics can lead to serious side effects, such as nausea, vomiting, and diarrhea, and can potentially disrupt the balance of beneficial bacteria in the gut [4]. However, there is no specific recorded instance of a fatal overdose directly attributed to Tigecycline.

In conclusion, while there is no publicly available information on the highest recorded Tigecycline dose before a fatality, it is crucial to adhere to the recommended dosage to avoid potential side effects and antibiotic resistance [5].

Sources:

1. "[Tigecycline (Intravenous)]". National Library of Medicine. <https://medlineplus.gov/druginfo/meds/a608042.html>.
2. "TIGECYCLINE [Tygacil]". DailyMed. <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=268d6e5e-6e77-4a1f-a082-f68b8a5a0e0d&type=display>.
3. "Tygacil (tigecycline)". Drugs.com. <https://www.drugs.com/pro/tygacil.html>.
4. "Antibiotics and Diarrhea". Mayo Clinic. <https://www.mayoclinic.org/diseases-conditions/diarrhea/expert-answers/antibiotics-and-diarrhea/faq-200583>.
5. "Tigecycline". DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/tigecycline>.