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There is no direct evidence linking Lipitor, a cholesterol-lowering drug, to the treatment of depression. However, some studies suggest that certain cholesterol-lowering drugs, specifically statins, may have an impact on depression, although the evidence is not conclusive [1].

When it comes to depression, several alternatives to Lipitor have been studied. Here are a few:

1. **Selective Serotonin Reuptake Inhibitors (SSRIs)**: These are the most commonly prescribed medications for depression. They work by increasing the levels of serotonin, a neurotransmitter in the brain that helps maintain mental balance [2]. Examples include fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro).

2. **Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)**: These medications affect both serotonin and norepinephrine, another neurotransmitter. They are also commonly used to treat depression. Examples include venlafaxine (Effexor) and duloxetine (Cymbalta) [2].

3. **Tricyclic Antidepressants (TCAs)**: These are older antidepressants that are typically used when other medications haven't worked. They can have more side effects than newer antidepressants [2].

4. **Monoamine Oxidase Inhibitors (MAOIs)**: These are used less frequently due to their potential for serious side effects. They're typically used when other medications haven't worked [2].

5. **Psychotherapy**: Also known as talk therapy, this can be used alone or in combination with medication. It involves talking with a mental health professional to learn skills to manage your symptoms [2].

6. **Lifestyle Changes**: Regular exercise, a healthy diet, adequate sleep, and stress management techniques can also help manage symptoms of depression [2].

Remember, it's important to consult with a healthcare provider for a proper diagnosis and treatment plan. They can provide guidance on the best course of action based on individual needs and circumstances.

Sources:
[1] "Statins and Depression: A Systematic Review and Meta-Analysis" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164835/
[2] "Depression" - Mayo Clinic - https://www.mayoclinic.org/diseases-conditions/depression/diagnosis-treatment/drc-20356013