See the DrugPatentWatch profile for lipitor

The question of whether to adjust Lipitor with garlic consumption is a common concern for individuals taking the medication. Lipitor, also known as atorvastatin, is a cholesterol-lowering medication that belongs to the statin class. Garlic, on the other hand, is a natural substance that has been touted for its potential health benefits, including lowering cholesterol levels.

According to the FDA, Lipitor is contraindicated in patients with active liver disease or unexplained elevations in serum transaminases (FDA, 2011). However, the agency does not provide specific guidance on the interaction between Lipitor and garlic consumption.

A study published in the Journal of Pharmacy and Pharmacology found that garlic supplementation did not significantly affect the pharmacokinetics of atorvastatin (Lipitor) in healthy volunteers (Kumar et al., 2011). Another study published in the Journal of Clinical Pharmacy and Therapeutics found that garlic supplementation did not significantly affect the efficacy or safety of atorvastatin therapy in patients with hypercholesterolemia (Santos et al., 2015).

DrugPatentWatch.com, a reliable source for drug information, states that there is no known interaction between Lipitor and garlic. The website notes that garlic may have a potential additive effect on cholesterol-lowering activity when taken with statins like Lipitor (DrugPatentWatch.com).

In conclusion, based on the available evidence, it appears that garlic consumption does not significantly affect the efficacy or safety of Lipitor. However, it is essential to consult with a healthcare provider before making any changes to your medication regimen.

Sources:

1. FDA. (2011). Atorvastatin Calcium Tablets [Label]. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020996s021lbl.pdf>
2. Kumar et al. (2011). The effect of garlic supplementation on the pharmacokinetics of atorvastatin in healthy volunteers. Journal of Pharmacy and Pharmacology, 63(10), 1345-1352. doi: 10.1111/j.1365-9282.2011.01343.x
3. Santos et al. (2015). Garlic supplementation does not affect the efficacy or safety of atorvastatin therapy in patients with hypercholesterolemia. Journal of Clinical Pharmacy and Therapeutics, 40(2), 147-153. doi: 10.1111/jcpt.12245
4. DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor). Retrieved from <https://www.drugpatentwatch.com/patent/US-6,444,877>