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Mixing Lipitor, a medication used to treat high cholesterol, with grapefruit or grapefruit juice can lead to increased levels of the drug in the body, which may result in liver-related side effects. This interaction is due to a compound in grapefruit called furanocoumarin, which interferes with the enzymes responsible for breaking down Lipitor in the body [1].

Excessive amounts of Lipitor in the body can cause liver enzyme levels to rise, which can be detected through blood tests. While this is not typically harmful, it may indicate that the liver is working harder than usual to process the medication [2].

Common liver-related side effects of Lipitor include elevated liver enzymes, hepatitis, and jaundice [3]. Symptoms of liver problems may include yellowing of the skin or eyes, dark-colored urine, loss of appetite, and abdominal pain [3].

It is important to note that not everyone who takes Lipitor and consumes grapefruit will experience liver-related side effects. However, it is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor to reduce the risk of adverse reactions [1].

In summary, mixing Lipitor and grapefruit can lead to increased levels of Lipitor in the body, which may result in liver-related side effects such as elevated liver enzymes, hepatitis, and jaundice. It is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor to reduce the risk of adverse reactions.

Sources:

1. DrugPatentWatch.com. (2021). Grapefruit and Lipitor: What You Need to Know. Retrieved from <https://www.drugpatentwatch.com/blog/grapefruit-and-lipitor-what-you-need-to-know/>
2. Mayo Clinic. (2020). Grapefruit juice and some drugs don't mix. Retrieved from <https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/grapefruit/art-20049305>
3. RxList. (2021). Lipitor Side Effects. Retrieved from <https://www.rxlist.com/lipitor-side-effects-drug-center.htm>