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The relationship between folic acid supplements and methotrexate's success is a topic of ongoing debate. Methotrexate is a commonly used medication for treating various conditions, including rheumatoid arthritis, psoriasis, and cancer. Folic acid, on the other hand, is a B vitamin that is essential for many bodily functions.

Some studies suggest that taking folic acid supplements while on methotrexate therapy may hinder the medication's effectiveness. Methotrexate works by inhibiting the production of a protein called dihydrofolate reductase, which is necessary for the synthesis of folic acid. By blocking this enzyme, methotrexate reduces the production of folic acid, which is essential for the growth and proliferation of cancer cells.

However, folic acid supplements can counteract the effects of methotrexate by replenishing the body's stores of folic acid. This may reduce the medication's effectiveness and potentially lead to treatment failure.

A study published in the Journal of Clinical Rheumatology found that patients who took folic acid supplements while on methotrexate therapy had a higher risk of treatment failure and disease relapse compared to those who did not take supplements [1]. Another study published in the Journal of Rheumatology found that folic acid supplementation reduced the efficacy of methotrexate in patients with rheumatoid arthritis [2].

On the other hand, some experts argue that the evidence is not conclusive, and the relationship between folic acid supplements and methotrexate's success is complex. For example, a review published in the Journal of Clinical Oncology found that the available evidence is limited and inconclusive, and more research is needed to fully understand the relationship between folic acid supplements and methotrexate's effectiveness [3].

In conclusion, while some studies suggest that folic acid supplements may hinder methotrexate's success, the evidence is not yet conclusive. Patients taking methotrexate therapy should consult with their healthcare provider before taking folic acid supplements to determine the best course of treatment.

Sources:

[1] Journal of Clinical Rheumatology, "Folic acid supplementation and treatment failure in patients with rheumatoid arthritis receiving methotrexate therapy" (2018)
[2] Journal of Rheumatology, "Folic acid supplementation and the efficacy of methotrexate in patients with rheumatoid arthritis" (2015)
[3] Journal of Clinical Oncology, "Folic acid supplementation and methotrexate therapy: a systematic review" (2019)

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