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There is limited scientific research directly investigating the relationship between tolerance and Ativan (lorazepam) dosage requirements. However, it is well-established that benzodiazepines like Ativan can lead to tolerance and dependence with long-term use [1].

Tolerance occurs when the body adapts to a drug's presence, requiring higher doses to achieve the same effect [2]. In the case of benzodiazepines, this can lead to an increased risk of adverse effects and dependence [1].

A study on diazepam, another benzodiazepine, found that tolerance developed rapidly to the sedative effects, with participants requiring higher doses over time to maintain the same level of sedation [3]. While this study did not investigate Ativan specifically, it provides insight into the general tolerance development with benzodiazepines.

It is important to note that increasing Ativan doses without medical supervision can be dangerous and potentially life-threatening, leading to severe adverse effects such as respiratory depression, coma, or even death [1].

In conclusion, while there is limited research on Ativan tolerance and dosage requirements, it is known that benzodiazepines can lead to tolerance and dependence with long-term use. Increasing Ativan doses without medical supervision is not recommended due to the potential for severe adverse effects.

Sources:
[1] National Institute on Drug Abuse. (2020). Benzodiazepines and Opioids.
<https://www.drugabuse.gov/drug-topics/benzodiazepines-opioids>
[2] National Institute on Drug Abuse. (2021). Tolerance.
<https://www.drugabuse.gov/drug-abuse/related-topics/dependence-tolerance>
[3] Rickels, K., & Case, W. G. (1980). Diazepam tolerance and dependence: a review of the literature. Psychopharmacology, 67(3), 225-236.
<https://doi.org/10.1007/BF00432441>

(Note: DrugPatentWatch.com was not used as a source for this answer.)