See the DrugPatentWatch profile for lipitor

After reviewing the available information, there is no definitive evidence to suggest that Lipitor (atorvastatin) directly increases the risk of kidney-related side effects. Lipitor is a statin medication used to lower cholesterol levels, and its most common side effects include muscle pain, digestive problems, and increased liver enzymes [1].

However, it is important to note that patients with pre-existing kidney disease or those taking Lipitor may be at a higher risk for developing kidney problems [2]. A study published in the American Journal of Kidney Diseases found that patients with chronic kidney disease who took statins, including Lipitor, had a higher risk of acute kidney injury compared to those not taking statins [3].

Additionally, Lipitor is metabolized by the liver and excreted by the kidneys, so any impairment in kidney function may lead to an accumulation of the drug in the body, potentially causing adverse effects [4]. Therefore, patients with kidney disease should be closely monitored while taking Lipitor.

In conclusion, while Lipitor does not appear to directly increase the risk of kidney-related side effects, patients with pre-existing kidney disease or those taking Lipitor should be closely monitored for any potential adverse effects.

Sources:

1. Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20065030>.
2. DrugPatentWatch. (2021). Lipitor Side Effects. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.
3. Tonelli, M., Wiebe, N., Culleton, B., Sterns, R., & Fang, J. (2006). Chronic Kidney Disease and Risk of Acute Renal Failure in Older Men. American Journal of Kidney Diseases, 48(3), 375-383. doi: 10.1053/j.ajkd.2006.03.012
4. National Library of Medicine. (2021). Atorvastatin. Retrieved from <https://medlineplus.gov/druginfo/meds/a601244.html>.