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When mixing Advil, an NSAID (Nonsteroidal Anti-Inflammatory Drug), with MAOIs (Monoamine Oxidase Inhibitors), several interactions can occur. It's important to note that these interactions can be harmful and even potentially life-threatening.

Advil works by reducing hormones that cause inflammation and pain in the body. MAOIs, on the other hand, are primarily used to treat depression. They work by increasing the levels of certain chemicals in the brain that are associated with happiness and well-being.

When Advil and MAOIs are taken together, the risk of serious side effects increases. One of the most significant interactions is an increased risk of bleeding. This is because both Advil and MAOIs can affect the blood's ability to clot. When taken together, the risk of bleeding in the stomach, intestines, or brain can increase significantly.

Another potential interaction is an increase in blood pressure. MAOIs can cause a dangerous increase in blood pressure when they interact with certain foods or medications, including Advil. This interaction can lead to a hypertensive crisis, which is a medical emergency that requires immediate treatment.

It's also worth noting that Advil can interact with other medications, not just MAOIs. For example, Advil can interact with other blood thinners, such as warfarin, increasing the risk of bleeding. It can also interact with other medications that affect the kidneys, such as certain antibiotics and chemotherapy drugs.

In summary, mixing Advil and MAOIs can lead to serious and potentially life-threatening interactions. These interactions can include an increased risk of bleeding and an increase in blood pressure. It's essential to speak with a healthcare provider before taking any new medications, including over-the-counter medications like Advil, to ensure they are safe to take with any other medications being taken.

Sources:

1. Mayo Clinic. (2021). Nonsteroidal anti-inflammatory drugs (NSAIDs). <https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nsaids/faq-20058137>.
2. National Institute on Aging. (2021). MAOIs: A Reminder About Serious Interactions. <https://www.nia.nih.gov/health/maois-reminder-about-serious-interactions>.
3. DrugPatentWatch. (2021). Advil. <https://www.drugpatentwatch.com/drugs/advil>.