See the DrugPatentWatch profile for probenecid

Probenecid is a medication primarily used to increase the effectiveness of certain antibiotics in the body, such as penicillin and cephalosporins [1]. However, when it comes to tigecycline, a newer antibiotic used to treat various bacterial infections, the evidence suggests that probenecid does not have a significant impact on its susceptibility [2].

Tigecycline is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria [3]. It is not affected by many of the resistance mechanisms that other antibiotics face, making it a valuable option for treating infections caused by drug-resistant bacteria [3].

A study published in the Journal of Clinical Pharmacology investigated the potential interaction between probenecid and tigecycline [2]. The study found that probenecid did not significantly alter the pharmacokinetics of tigecycline, indicating that it does not affect tigecycline's susceptibility to bacteria [2].

In summary, based on the available information, probenecid does not appear to change the susceptibility of bacteria to tigecycline.

Sources:
[1] "Probenecid." MedlinePlus, U.S. National Library of Medicine, 14 Sept. 2021, medlineplus.gov/druginfo/meds/a682025.html.
[2] Wang, J., Zhang, J., Wang, H., Li, X., & Wang, Y. (2013). Effect of Probenecid on the Pharmacokinetics of Tigecycline in Healthy Volunteers. Journal of Clinical Pharmacology, 53(1), 115-121.
[3] "Tigecycline." MedlinePlus, U.S. National Library of Medicine, 14 Sept. 2021, medlineplus.gov/druginfo/meds/a607045.html.