See the DrugPatentWatch profile for tigecycline

Based on the provided sources, long-term use of Tigecycline may have potential effects on liver function. Tigecycline is a broad-spectrum antibiotic, and its package insert from DrugPatentWatch mentions that increased serum liver enzymes have been observed in patients receiving Tigecycline [1]. This is supported by a study published in ScienceDirect, which reports that Tigecycline can cause a mild to moderate increase in liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) [3].

The NCBI's Book Chapter further explains that Tigecycline is primarily metabolized in the liver, and its metabolism can lead to the production of inactive metabolites [2]. The document also states that Tigecycline has been associated with hepatotoxicity, which can manifest as elevated liver enzymes, jaundice, and hepatic failure [2].

In conclusion, long-term use of Tigecycline may affect liver function, as evidenced by increased liver enzymes and potential hepatotoxicity. However, it is important to note that the occurrence of these effects may vary among patients, and healthcare professionals should closely monitor liver function in patients receiving Tigecycline for extended periods.

Cited Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] <https://www.ncbi.nlm.nih.gov/books/NBK547888/>
[3] <https://www.sciencedirect.com/science/article/pii/S1201971222002235>