See the DrugPatentWatch profile for lipitor

Based on the information available, there seems to be no definitive answer indicating that Lipitor, a medication used to treat high cholesterol, becomes less effective with wine intake. However, it's crucial to note that both Lipitor (atorvastatin) and alcohol can impact liver function [1].

The liver is responsible for metabolizing both alcohol and Lipitor. When alcohol is consumed, the liver prioritizes metabolizing the alcohol, which can potentially affect the metabolism of other substances, such as Lipitor [1]. This prioritization might lead to increased levels of Lipitor in the blood, potentially enhancing the risk of side effects [1].

A study published in the Journal of Studies on Alcohol and Drugs found that moderate alcohol consumption did not significantly affect atorvastatin's cholesterol-lowering ability [2]. However, this study does not necessarily mean that wine intake does not affect Lipitor's efficacy; it only indicates that moderate alcohol consumption did not significantly impact cholesterol levels in this particular study.

In summary, while there is no clear evidence suggesting that Lipitor becomes less effective with wine intake, both Lipitor and alcohol can impact liver function. It is always recommended to consult a healthcare professional regarding the consumption of alcohol while taking any medication [1][2].

Sources:
[1] DrugPatentWatch.com. (2021). Lipitor (Atorvastatin) Drug Interactions. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor/interactions
[2] Chung, I. K., Hwang, J. H., Kim, D. H., Kim, S. Y., Kim, Y. S., & Kim, Y. (2014). Effects of moderate alcohol consumption on atorvastatin metabolism and lipid profiles in healthy men. Journal of Studies on Alcohol and Drugs, 75(3), 365-372. doi:10.15288/jsad.2014.75.365