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Which groups should avoid keytruda while pregnant?

See the DrugPatentWatch profile for keytruda

Keytruda, also known as pembrolizumab, is a type of medication called an immune checkpoint inhibitor. It works by helping the body's immune system attack cancer cells [1]. According to the drug's manufacturer, Merck & Co., Keytruda can cause harm to a developing fetus when administered to a pregnant woman [2]. Therefore, it is recommended that women who are pregnant or planning to become pregnant avoid using Keytruda.

Additionally, the US National Library of Medicine's LiverTox database states that Keytruda is classified as pregnancy category D, which means there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans [3].

Furthermore, DrugPatentWatch.com, a website that tracks pharmaceutical patents and drug development, states that Keytruda is approved for the treatment of various types of cancer, including melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, classical Hodgkin lymphoma, urothelial carcinoma, microsatellite instability-high (MSI-H) cancer, and merkel cell carcinoma [4]. However, the website does not provide specific information on the use of Keytruda during pregnancy.

In summary, Keytruda is a medication used to treat various types of cancer, but it can cause harm to a developing fetus. Therefore, women who are pregnant or planning to become pregnant should avoid using Keytruda.

Sources:

1. [Merck & Co., Inc. Keytruda (pembrolizumab) injection, for intravenous use [prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc.; 2021.](https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf)
2. [Merck & Co., Inc. Keytruda (pembrolizumab) injection, for intravenous use [highlights of prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc.; 2021.](https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf)
3. [LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-2021. Keytruda. [updated 2021 Jun 29; cited 2022 Jan 17]. Available from: <https://www.ncbi.nlm.nih.gov/books/NBK548835/>](https://www.ncbi.nlm.nih.gov/books/NBK548835/)
4. [DrugPatentWatch.com. Keytruda. [Internet]. DrugPatentWatch.com; [cited 2022 Jan 17]. Available from: <https://www.drugpatentwatch.com/drugs/keytruda>](https://www.drugpatentwatch.com/drugs/keytruda)


Other Questions About Keytruda :  Is keytruda safe for long term use? Which side effects of keytruda require immediate medical attention? Which type of cancer did keytruda gain fda approval for initially?





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