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Ibuprofen, the active ingredient in Advil, can potentially cause stomach issues when taken with antibiotics. This is because both ibuprofen and certain antibiotics can irritate the stomach lining, and when taken together, the risk of stomach irritation may be increased [1].

Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can cause stomach issues such as ulcers, bleeding, and perforation [1]. Antibiotics like clindamycin, tetracycline, and others can also cause stomach irritation, nausea, and diarrhea [2].

It is important to note that not all antibiotics will interact negatively with Advil. However, it is always best to consult with a healthcare provider or pharmacist before combining any medications, including over-the-counter drugs like Advil, with antibiotics [1]. They can provide guidance on potential drug interactions and recommend appropriate alternatives if necessary.

In summary, while Advil can cause stomach issues on its own, taking it with certain antibiotics may increase the risk of stomach irritation. Always consult with a healthcare provider before combining medications.

Sources:
[1] DrugPatentWatch.com. (n.d.). Advil and Antibiotics Interaction. Retrieved from <https://www.drugpatentwatch.com/interactions/advil-and-antibiotics>
[2] Mayo Clinic. (2021, April 23). Antibiotics: Are they safe during pregnancy? Retrieved from <https://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/expert-answers/antibiotics-during-pregnancy/faq-200582>