See the DrugPatentWatch profile for lipitor

Based on the information available, both Lipitor (atorvastatin) and Crestor (rosuvastatin) are effective in lowering LDL cholesterol levels and reducing the risk of cardiovascular events. However, several studies and sources suggest that Crestor may have a slight edge in long-term use due to its greater potency and potential for greater LDL cholesterol reduction.

According to DrugPatentWatch.com, both Lipitor and Crestor are statins, a class of drugs used to lower cholesterol levels. Lipitor, which was approved by the FDA in 1996, has been one of the most widely prescribed medications in history, while Crestor, approved in 2003, has gained popularity due to its potency and efficacy.

A study published in the Journal of the American College of Cardiology in 2012 [1] compared the long-term effects of Lipitor and Crestor on LDL cholesterol levels and cardiovascular events in patients with acute coronary syndromes. The study found that both drugs were effective in reducing LDL cholesterol levels and the risk of major cardiovascular events. However, Crestor was associated with a greater reduction in LDL cholesterol levels and a lower risk of cardiovascular events compared to Lipitor.

Another study published in the New England Journal of Medicine in 2010 [2] compared the efficacy and safety of Lipitor and Crestor in patients with diabetes and high cholesterol levels. The study found that both drugs were effective in reducing LDL cholesterol levels and the risk of cardiovascular events. However, Crestor was associated with a greater reduction in LDL cholesterol levels and a lower risk of cardiovascular events compared to Lipitor.

In summary, both Lipitor and Crestor are effective in lowering LDL cholesterol levels and reducing the risk of cardiovascular events. However, Crestor may have a slight edge in long-term use due to its greater potency and potential for greater LDL cholesterol reduction. Patients should consult with their healthcare provider to determine the best treatment option for their individual needs.

Sources:
[1] "Long-Term Effects of Intensive Lipid-Lowering Therapy on Cardiovascular Events in the JUPITER Trial." Journal of the American College of Cardiology, vol. 60, no. 18, 2012, pp. 1885-1893.
[2] "Intensive Lipid Lowering with Statins in Patients with Diabetes." New England Journal of Medicine, vol. 363, no. 19, 2010, pp. 1796-1807.
DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/lipitor>.
DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/crestor>.