See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections, community-acquired pneumonia, and diabetic foot infections [1]. However, the effectiveness of tigecycline can be reduced due to several factors, such as the emergence of drug-resistant bacteria and improper use of the antibiotic. Here are some ways to prevent the reduced effectiveness of tigecycline:

1. **Appropriate Use of Tigecycline**: Tigecycline should be used only to treat infections caused by susceptible bacteria, as determined by antibiotic susceptibility testing [1]. Using tigecycline to treat infections caused by bacteria that are resistant to the drug can lead to treatment failure and increased antibiotic resistance.

2. **Proper Dosage and Duration**: Healthcare providers should follow the recommended dosage and duration of tigecycline therapy to ensure the effective treatment of bacterial infections [1]. Inadequate dosing or shortening the duration of therapy can lead to treatment failure and the development of antibiotic resistance.

3. **Combination Therapy**: In some cases, using tigecycline in combination with other antibiotics may be more effective in treating certain infections and may help prevent the development of antibiotic resistance [2].

4. **Antibiotic Stewardship Programs**: Implementing antibiotic stewardship programs in healthcare settings can help promote the appropriate use of antibiotics, including tigecycline, and reduce the emergence of antibiotic-resistant bacteria [3].

5. **Surveillance and Monitoring**: Regular surveillance and monitoring of bacterial susceptibility to tigecycline can help detect the emergence of drug-resistant bacteria and inform the development of strategies to prevent further reductions in tigecycline effectiveness [1].

Sources:

1. [Tigecycline: DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/tigecycline)
2. [Tigecycline: Clinical Pharmacology](https://www.ncbi.nlm.nih.gov/books/NBK557832/)
3. [Antibiotic Stewardship Programs: CDC](https://www.cdc.gov/antibiotic-use/healthcare/stewardship-programs.html)