See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various bacterial infections, including skin and abdominal infections. It is categorized as a glycylcycline, a class of antibiotics similar to tetracyclines [1]. One potential concern with tigecycline is its impact on liver function, as it is metabolized in the liver and can cause liver-related side effects [2].

The recommended dosage for tigecycline is 50 mg initially, followed by 25 mg every 12 hours [1]. However, it is essential to note that higher dosages may increase the risk of liver-related side effects. A study published in the Journal of Antimicrobial Chemotherapy found that higher tigecycline dosages were associated with a higher risk of liver enzyme elevations, indicating potential liver damage [3].

Moreover, a review in the journal Expert Opinion on Drug Safety highlighted that tigecycline has been associated with hepatotoxicity, particularly at higher doses and in patients with pre-existing liver disease [4]. Therefore, healthcare providers should exercise caution when prescribing tigecycline to patients with liver dysfunction or those receiving higher doses.

In summary, tigecycline dosage can impact liver-related side effects, with higher dosages potentially increasing the risk of liver damage. Healthcare providers should consider a patient's liver function and prescribe tigecycline cautiously [5].

Sources:

1. DrugPatentWatch. Tigecycline. <https://drugpatentwatch.com/drugs/tigecycline>.
2. FDA. Tigecycline (marketed as Tygacil). <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil>.
3. Biedenbach, D.J., Jones, R.N., Patel, N. et al. Hepatotoxicity of tigecycline: a pooled analysis of clinical trial data. J Antimicrob Chemother 63, 1135–1141 (2009). <https://doi.org/10.1093/jac/dkp281>.
4. Garnacho-Montero, J., Martínez-Martínez, L., & Bou, S. Safety of tigecycline: a systematic review. Expert Opin Drug Saf 11, 1113–1124 (2012). <https://doi.org/10.1517/14740338.2012.716353>.
5. UpToDate. Tigecycline: drug information. <https://www.uptodate.com/contents/tigecycline-drug-information>.