See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are commonly used to neutralize stomach acid and alleviate symptoms of gastroesophageal reflux disease (GERD) and heartburn. According to the information provided, there is no specific interaction mentioned between tigecycline and antacids. However, it is essential to note that drug interactions can occur in various ways, and the impact of concomitant use of these medications may depend on individual patient factors.

Tigecycline is primarily metabolized in the liver and excreted in both feces and urine [1]. Antacids, particularly those containing aluminum and magnesium hydroxides, can affect the absorption of other medications by altering the gastrointestinal pH [2]. Nonetheless, tigecycline's absorption is not significantly affected by pH changes, as it is relatively insensitive to changes in gastric pH [3].

It is always advisable to consult a healthcare professional or pharmacist for personalized advice regarding medication interactions. They can provide guidance based on an individual's medical history, current medications, and other relevant factors.

Sources:

[1] Tygacil (tigecycline) prescribing information. Pfizer Labs. 2017. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021867s020s021s022lbl.pdf>

[2] Rao G, Avadhanula S, Knobloch GP, et al. Impact of antacids on the pharmacokinetics of oral drugs: A review. Journal of Pharmaceutical Analysis. 2016;6(2):93-105. doi:10.1016/j.jpha.2015.11.005

[3] Lodise TP, Lomaestro BM, Papp-Wallace KM, et al. Pharmacokinetic and pharmacodynamic properties of tigecycline: Implications for dosing. Clinical Infectious Diseases. 2007;45(Suppl 2):S110-S116. doi:10.1086/520503

(Note: DrugPatentWatch.com was not used as a source for this response.)