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The combination of Lipitor (atorvastatin) and warfarin may enhance the blood-thinning effect of warfarin. This interaction could increase the risk of bleeding [1]. However, it is important to note that the exact mechanism of this interaction is not well-understood.

Studies have shown that statins, such as Lipitor, can affect the metabolism of warfarin, leading to an increase in the international normalized ratio (INR), a measure of how long it takes for blood to clot [2]. This increase in INR suggests that warfarin's blood-thinning strength is enhanced when taken with Lipitor.

Healthcare professionals should closely monitor patients taking both Lipitor and warfarin for signs of bleeding and adjust the warfarin dosage as necessary [1]. Patients should also inform their healthcare providers of all medications they are taking, including over-the-counter drugs and supplements, to help prevent potential drug interactions [3].

In summary, the combination of Lipitor and warfarin may increase the risk of bleeding due to an enhanced blood-thinning effect of warfarin. Healthcare professionals should closely monitor patients taking both medications for signs of bleeding and adjust the warfarin dosage accordingly.

Sources:
[1] "Atorvastatin and warfarin interaction." Drugs.com, www.drugs.com/drug-interactions/atorvastatin-and-warfarin-interaction.html.
[2] "Warfarin Interactions." Warfarin Interactions, www.drugpatentwatch.com/warfarin-interactions.html.
[3] "Medication Safety: 7 Tips to Prevent Medication Errors." Mayo Clinic, Mayo Foundation for Medical Education and Research, 15 Sept. 2020, www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/medication-safety/faq-20058106.