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When considering medication interactions with Lipitor (atorvastatin), it's crucial to be aware of potential drug interactions. Lipitor is a statin, a class of drugs used to lower cholesterol levels. According to Drugs.com, Lipitor can interact with various pain medications, particularly those that can increase the level of Lipitor in the blood, leading to a higher risk of side effects [1].

Gemfibrozil, a medication used to treat high cholesterol and triglyceride levels, can significantly increase Lipitor levels in the blood, leading to a higher risk of side effects [1]. Therefore, it is usually not recommended to combine these two drugs.

Certain NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen, naproxen, and celecoxib can also interact with Lipitor, although the risk is generally low [1]. However, it is always advisable to consult a healthcare professional or pharmacist before combining Lipitor with any pain medication.

In some cases, the interaction may be manageable by adjusting the dosage or monitoring the patient more closely for side effects [1].

In summary, while Lipitor can interact with some pain medications, the risk is generally low. However, it is essential to consult a healthcare professional or pharmacist before combining Lipitor with any pain medication.

Sources:
[1] <https://www.drugs.com/drug-interactions/atorvastatin-with-ibuprofen-392-187-513-1189-198.html>