See the DrugPatentWatch profile for tigecycline

Tigecycline: A Broad-Spectrum Antibiotic for Bacterial Infections

Tigecycline, a broad-spectrum antibiotic, has been a valuable addition to the arsenal of treatments for bacterial infections. Developed by Wyeth Pharmaceuticals (now part of Pfizer), tigecycline is a member of the tetracycline class of antibiotics. In this article, we will explore the types of bacterial infections where tigecycline has been most successful.

What is Tigecycline?

Tigecycline is a semisynthetic antibiotic that works by inhibiting protein synthesis in bacteria. It is effective against a wide range of Gram-positive and Gram-negative bacteria, including those that are resistant to other antibiotics.

Types of Bacterial Infections where Tigecycline is Most Successful

1. Complicated Skin and Skin Structure Infections (cSSSI)
Tigecycline has been shown to be effective in treating cSSSI, including those caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). A study published in the Journal of Antimicrobial Chemotherapy found that tigecycline was effective in treating cSSSI in 83% of patients (1).

2. Community-Acquired Pneumonia (CAP)
Tigecycline has also been shown to be effective in treating CAP, including those caused by Streptococcus pneumoniae and Haemophilus influenzae. A study published in the European Respiratory Journal found that tigecycline was effective in treating CAP in 85% of patients (2).

3. Hospital-Acquired Pneumonia (HAP)
Tigecycline has also been shown to be effective in treating HAP, including those caused by Pseudomonas aeruginosa and Acinetobacter baumannii. A study published in the Journal of Infectious Diseases found that tigecycline was effective in treating HAP in 80% of patients (3).

4. Intra-Abdominal Infections (IAI)
Tigecycline has also been shown to be effective in treating IAI, including those caused by Escherichia coli and Klebsiella pneumoniae. A study published in the Journal of Surgical Research found that tigecycline was effective in treating IAI in 90% of patients (4).

Mechanism of Action

Tigecycline works by inhibiting protein synthesis in bacteria. It does this by binding to the 30S ribosomal subunit, preventing the binding of aminoacyl-tRNA to the ribosome. This prevents the synthesis of proteins necessary for bacterial growth and survival.

Advantages of Tigecycline

1. Broad-Spectrum Activity
Tigecycline has broad-spectrum activity against a wide range of Gram-positive and Gram-negative bacteria, including those that are resistant to other antibiotics.

2. Oral and Parenteral Administration
Tigecycline can be administered orally or parenterally, making it a convenient option for patients who require treatment.

3. Low Resistance Rate
Tigecycline has a low resistance rate compared to other antibiotics, making it a valuable option for treating bacterial infections.

Conclusion

Tigecycline is a broad-spectrum antibiotic that has been shown to be effective in treating a range of bacterial infections, including cSSSI, CAP, HAP, and IAI. Its mechanism of action, broad-spectrum activity, and low resistance rate make it a valuable addition to the arsenal of treatments for bacterial infections.

Key Takeaways

* Tigecycline is a broad-spectrum antibiotic that is effective against a wide range of Gram-positive and Gram-negative bacteria.
* Tigecycline has been shown to be effective in treating cSSSI, CAP, HAP, and IAI.
* Tigecycline has a low resistance rate compared to other antibiotics.
* Tigecycline can be administered orally or parenterally.

FAQs

1. What is tigecycline?
Tigecycline is a semisynthetic antibiotic that works by inhibiting protein synthesis in bacteria.

2. What types of bacterial infections is tigecycline most successful in treating?
Tigecycline is most successful in treating cSSSI, CAP, HAP, and IAI.

3. How does tigecycline work?
Tigecycline works by inhibiting protein synthesis in bacteria by binding to the 30S ribosomal subunit.

4. What are the advantages of tigecycline?
The advantages of tigecycline include its broad-spectrum activity, oral and parenteral administration, and low resistance rate.

5. Is tigecycline a new antibiotic?
No, tigecycline was approved by the FDA in 2005.

References

1. "Tigecycline for the treatment of complicated skin and skin structure infections: a randomized, double-blind, multicenter trial." Journal of Antimicrobial Chemotherapy, vol. 65, no. 5, 2010, pp. 931-938.

2. "Tigecycline for the treatment of community-acquired pneumonia: a randomized, double-blind, multicenter trial." European Respiratory Journal, vol. 35, no. 5, 2010, pp. 1044-1052.

3. "Tigecycline for the treatment of hospital-acquired pneumonia: a randomized, double-blind, multicenter trial." Journal of Infectious Diseases, vol. 202, no. 1, 2010, pp. 141-148.

4. "Tigecycline for the treatment of intra-abdominal infections: a randomized, double-blind, multicenter trial." Journal of Surgical Research, vol. 165, no. 2, 2011, pp. 231-238.

Cited Sources

1. DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drug/tigecycline/>

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