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Ibuprofen, commonly known by the brand name Advil, and acetaminophen, or Tylenol, are both over-the-counter medications used to treat pain and reduce fever. While both drugs are generally safe for most people, they can cause side effects, especially when not used as directed.

Advil, an nonsteroidal anti-inflammatory drug (NSAID), can cause stomach upset, including nausea, vomiting, and abdominal pain. Long-term use of Advil can lead to more serious side effects, such as stomach ulcers, bleeding, and kidney damage [1]. In rare cases, Advil can also cause allergic reactions, including rash, hives, and difficulty breathing [2].

Tylenol, a non-narcotic analgesic, is generally well tolerated, but it can cause side effects such as stomach pain, nausea, and loss of appetite [3]. In rare cases, Tylenol can cause more serious side effects, including liver damage and allergic reactions [4].

It is important to follow the dosage instructions on the label and to talk to a healthcare provider before taking these medications, especially if you have any underlying health conditions or are taking other medications.

Sources:
[1] "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/druginfo/meds/a682137.html.
[2] "Ibuprofen Side Effects: Common, Severe, Long Term." RxList, RxList, 11 Jan. 2022, www.rxlist.com/ibuprofen/side-effects-drugs.htm.
[3] "Acetaminophen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/druginfo/meds/a682139.html.
[4] "Acetaminophen Side Effects: Common, Severe, Long-Term." RxList, RxList, 11 Jan. 2022, www.rxlist.com/acetaminophen-side-effects-drug-center.htm.