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When using Lipitor, a statin medication used to lower cholesterol levels, certain signs may indicate the need for liver function tests. These signs include:

1. Persistent fatigue or weakness: Prolonged feelings of tiredness or lack of energy may suggest issues with liver function [1].
2. Loss of appetite: A decrease or loss of appetite can be a sign of liver problems [1].
3. Unexplained weight loss: Sudden or unexplained weight loss might indicate liver issues [1].
4. Upper abdominal pain: Discomfort or pain in the upper right area of the abdomen can be a sign of liver-related concerns [1].
5. Nausea or vomiting: These symptoms could indicate liver problems, especially when accompanied by other signs [1].
6. Dark urine: This can be a sign of liver dysfunction, as the liver plays a crucial role in processing waste products [1].
7. Pale or clay-colored stools: This change in stool color could indicate a problem with the liver or bile ducts [1].
8. Yellowing of the skin or eyes (jaundice): Jaundice is a common sign of liver disease [1].

It is essential to consult a healthcare professional if any of these signs occur while taking Lipitor. Regular monitoring of liver function may be recommended, especially during the initial stages of treatment or if there is a history of liver disease [2].

Sources:
[1] Mayo Clinic. (2021). Symptoms of liver disease. Retrieved from https://www.mayoclinic.org/diseases-conditions/liver-problems/symptoms-causes/syc-20374502
[2] DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor