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Tylenol (acetaminophen) and Advil (ibuprofen) are two commonly used over-the-counter (OTC) medications for pain relief and fever reduction. While both are generally considered safe when used as directed, there are potential risks associated with their regular, daily use.

Tylenol (acetaminophen) risks:

- Liver damage: High doses of acetaminophen can lead to liver toxicity and even liver failure [1]. The risk increases when consuming alcohol or taking other medications that contain acetaminophen [1].
- Allergic reactions: Some people may experience allergic reactions to acetaminophen, which can range from mild skin rashes to life-threatening anaphylaxis [1].
- Rare skin reactions: Severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are rare but potentially fatal side effects of acetaminophen use [1].

Advil (ibuprofen) risks:

- Stomach ulcers and bleeding: Ibuprofen can irritate the lining of the stomach, leading to ulcers and internal bleeding, especially in long-term users or those taking high doses [2].
- Cardiovascular risks: Ibuprofen may increase the risk of heart attack and stroke, particularly in those with pre-existing heart conditions or risk factors [2].
- Kidney damage: Long-term use of ibuprofen can lead to kidney damage or kidney failure, particularly in individuals with pre-existing kidney issues or those taking high doses [2].
- Allergic reactions: Similar to acetaminophen, some people may experience allergic reactions to ibuprofen, which can range from mild skin rashes to life-threatening anaphylaxis [2].

It is essential to follow the recommended dosage and usage guidelines for both Tylenol and Advil to minimize the risks associated with their use. If you have any concerns about taking these medications, consult your healthcare provider or pharmacist.

Sources:

1. "Acetaminophen." National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, 1 Sept. 2017, <https://www.niddk.nih.gov/health-information/patient-fact-sheets/acetaminophen>.
2. "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, <https://medlineplus.gov/druginfo/meds/a682035.html>.
3. "Acetaminophen and Ibuprofen: Similar but Different." DrugPatentWatch, 2022, <https://www.drugpatentwatch.com/blog/acetaminophen-and-ibuprofen-similar-but-different/>.