See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. While the drug is generally well-tolerated, there are potential side effects associated with its use, some of which may be related to age.

According to the American College of Rheumatology, methotrexate can cause side effects such as nausea, mouth sores, and fatigue [2]. Older adults may be more susceptible to these side effects due to age-related changes in drug metabolism and elimination [3]. Additionally, methotrexate can increase the risk of infections, which can be more severe in older adults due to a weakened immune system [4].

Furthermore, methotrexate can have adverse effects on the liver and kidneys, which can be of particular concern in older adults [5]. Therefore, regular monitoring of liver and kidney function is recommended for older adults taking methotrexate [6].

It is important to note that the risk of side effects associated with methotrexate use may vary depending on the individual's age, overall health, and other factors [7]. Therefore, it is essential to consult with a healthcare provider to determine the appropriate dosage and monitoring schedule for each individual.

In summary, while methotrexate can be an effective treatment for various conditions, older adults may be at increased risk of certain side effects due to age-related changes in drug metabolism and elimination. Regular monitoring of liver and kidney function is recommended for older adults taking methotrexate.

Sources:

1. DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>.
2. American College of Rheumatology. (n.d.). Methotrexate. Retrieved from <https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Medications/Methotrexate>.
3. National Institute on Aging. (2021). Age Page: Aging Changes in Drug Metabolism. Retrieved from <https://www.nia.nih.gov/health/aging-changes-drug-metabolism>.
4. National Institute on Aging. (2021). Age Page: Aging Changes in Immune Function. Retrieved from <https://www.nia.nih.gov/health/aging-changes-immune-function>.
5. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/side-effects/drg-20063034>.
6. UpToDate. (2021). Patient education: Methotrexate (Beyond the Basics). Retrieved from <https://www.uptodate.com/contents/methotrexate-beyond-the-basics>.
7. American College of Rheumatology. (n.d.). Methotrexate. Retrieved from <https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Medications/Methotrexate>.