See the DrugPatentWatch profile for advil

According to the sources you provided, there is a possibility that Advil, a brand of ibuprofen, may increase the side effects of antidepressants. However, it is important to note that individual reactions can vary, and it is always recommended to consult with a healthcare professional for personalized advice.

The first source you provided, Drug Patent Watch, provides information on the active ingredient in Advil, which is ibuprofen. Ibuprofen belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). While this source does not specifically mention the interaction between Advil and antidepressants, it does provide general information about the drug.

The second source, Mayo Clinic, is a reputable medical institution. It explains that combining certain medications, including NSAIDs like Advil, with antidepressants can increase the risk of side effects. Specifically, it mentions that NSAIDs can interfere with the effectiveness of certain antidepressants, potentially leading to a condition called serotonin syndrome. Serotonin syndrome is a potentially serious condition characterized by symptoms such as agitation, rapid heartbeat, high blood pressure, dilated pupils, and others. It is important to note that this risk is not exclusive to Advil but applies to all NSAIDs.

The third source, a study published in the National Center for Biotechnology Information (NCBI) database, explores the potential interaction between ibuprofen and selective serotonin reuptake inhibitors (SSRIs), a common class of antidepressants. The study found that ibuprofen can interfere with the metabolism of SSRIs, potentially leading to increased levels of the medication in the body. This could result in an increased risk of side effects associated with SSRIs.

To summarize, the sources suggest that Advil, as an NSAID, may increase the risk of side effects when taken with antidepressants. These side effects may include serotonin syndrome and an increased concentration of antidepressant medication in the body. It is crucial to consult with a healthcare professional before combining these medications to ensure your safety and well-being.

Sources:
[1] Drug Patent Watch - https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Mayo Clinic - https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970
[3] NCBI - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/