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Yes, grapefruit juice can interfere with Lipitor (atorvastatin), a medication used to treat high cholesterol levels. This interaction can lead to increased levels of atorvastatin in the blood, which may increase the risk of side effects such as muscle damage and kidney problems [1].

The interaction occurs because certain compounds in grapefruit juice, such as furanocoumarins, can inhibit an enzyme in the intestines called CYP3A4, which is responsible for breaking down atorvastatin and other medications [1][2]. As a result, more of the drug enters the bloodstream and remains in the body for a longer period of time, increasing the risk of adverse effects.

It is important to note that the interaction can occur with both fresh grapefruit juice and grapefruit juice supplements, as well as with other citrus juices such as pomelo and Seville oranges [1].

Therefore, it is recommended to avoid consuming grapefruit juice and other citrus juices while taking Lipitor or other statin medications, and to consult with a healthcare provider or pharmacist for personalized advice [1].

Sources:

[1] "Grapefruit Juice and Some Drugs Don't Mix." U.S. Food and Drug Administration, FDA, 13 Jan. 2020, [www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix](http://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix).

[2] "Atorvastatin (Lipitor) Drug Interactions." Drugs.com, Drugs.com, [www.drugs.com/drug-interactions/atorvastatin-with-food-135-136.html](http://www.drugs.com/drug-interactions/atorvastatin-with-food-135-136.html).

[3] "Atorvastatin (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, [www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20068131](http://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20068131).

[4] "Atorvastatin (Lipitor) Patent Expiration and Generic Entry." DrugPatentWatch, DrugPatentWatch, [www.drugpatentwatch.com/drugs/atorvastatin](http://www.drugpatentwatch.com/drugs/atorvastatin).