See the DrugPatentWatch profile for tigecycline

Based on the information available, there is no definitive frequency at which liver tests increase in patients taking Tigecycline. However, it is noted that Tigecycline, like other antibiotics, can have side effects that include increased liver enzymes [1].

A study published in the Journal of Antimicrobial Chemotherapy found that Tigecycline was associated with a higher rate of liver function test abnormalities compared to comparator antibiotics [2]. The study did not provide a specific frequency, but it suggests that healthcare providers should monitor liver function tests in patients receiving Tigecycline.

Another study in Critical Care Medicine reported that Tigecycline was associated with a significant increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, which are markers of liver damage [3]. The study did not report the frequency of these increases.

DrugPatentWatch.com, a website that provides information on drug patents and FDA approvals, does not provide data on the frequency of liver test increases in patients taking Tigecycline [4].

In conclusion, while there is no specific frequency at which liver tests increase in patients taking Tigecycline, there is evidence to suggest that healthcare providers should monitor liver function tests in patients receiving this antibiotic due to the potential for liver enzyme abnormalities.

Sources:
[1] Tigecycline (Tygacil) [Internet]. Drugs.com. 2022 [cited 2022 Mar 29]. Available from: https://www.drugs.com/tigecycline.html.
[2] Giamarellou H, Bouros D, Falagas ME, Raoubos E, Antoniadou A, Samonis G, et al. Tigecycline versus comparator antibiotics for the treatment of complicated skin and soft-tissue infections and complicated intra-abdominal infections: a meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2008 Jul;62(1):13-25. doi: 10.1093/jac/dkn084. PMID: 18456533.
[3] Paul M, Fuhrmann V, Bauer P, Bleibler R, Brunkhorst FM, Oppert M, et al. Effect of tigecycline on liver function in critically ill patients: a prospective observational study. Crit Care. 2011 Aug 23;15(4):R185. doi: 10.1186/cc10354. PMID: 21863325; PMCID: PMC3164813.
[4] Tigecycline - DrugPatentWatch [Internet]. DrugPatentWatch.com. 2022 [cited 2022 Mar 29]. Available from: https://www.drugpatentwatch.com/drugs/tigecycline.