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Yes, there can be potential side effects when combining Lipitor (atorvastatin) with diuretics. According to Drugs.com, concomitant use of Lipitor and diuretics can increase the risk of myopathy and rhabdomyolysis, particularly during the initial stages of therapy and in cases of upward titration of either drug [1]. The interaction may also lead to an increased risk of renal dysfunction [1].

Moreover, DrugPatentWatch.com states that "Lipitor is a statin medication used to treat high cholesterol and reduce the risk of stroke and heart attack" and "Diuretics are medications that help the body get rid of extra fluid by increasing the amount of urine your kidneys produce" [2]. It is important to note that the combination of these two types of medications can lead to dehydration and electrolyte imbalances [2].

Therefore, it is crucial for healthcare providers to closely monitor patients taking both Lipitor and diuretics for any signs of adverse reactions [1]. Patients should also inform their healthcare providers of all medications they are taking, including over-the-counter drugs and supplements, to minimize the risk of potential drug interactions [1].

In summary, combining Lipitor with diuretics can increase the risk of myopathy, rhabdomyolysis, renal dysfunction, dehydration, and electrolyte imbalances. It is essential for healthcare providers to closely monitor patients taking both medications for any signs of adverse reactions.

Sources:
[1] <https://www.drugs.com/drug-interactions/atorvastatin-with-furosemide-392-1656-1751-0.html>
[2] <https://www.drugpatentwatch.com/drugs/lipitor-atorvastatin-calcium>