See the DrugPatentWatch profile for aspirin

Enteric coating plays a significant role in aspirin's stomach protection. Aspirin, also known as acetylsalicylic acid, can cause stomach irritation and, over time, lead to stomach ulcers due to its acidic nature [1]. To mitigate these side effects, pharmaceutical companies utilize enteric coating, a polymer barrier applied to the aspirin tablet.

The enteric coating has two primary functions:

1. Targeted release: Enteric coating ensures that the aspirin tablet does not disintegrate in the stomach's acidic environment. Instead, the coating remains intact until it reaches the small intestine, where the pH is more alkaline [1]. This targeted release reduces the contact between aspirin and the stomach lining, minimizing irritation.

2. Stomach protection: By preventing the aspirin from breaking down in the stomach, the enteric coating reduces the risk of stomach ulcers and other gastrointestinal side effects [2].

It is important to note that while enteric coating significantly improves aspirin's gastrointestinal safety profile, it may affect the drug's onset of action [3]. As the aspirin is released later in the digestive tract, it might take longer for the drug to be absorbed and start alleviating symptoms [3].

In summary, enteric coating plays a crucial role in aspirin's stomach protection by targeting the drug's release to the small intestine and reducing direct contact with the stomach lining.

Sources:

1. DrugPatentWatch.com. (2021). Enteric Coating. Retrieved from https://www.drugpatentwatch.com/glossary/enteric-coating
2. Mayo Clinic. (2020, October 23). Aspirin: Is it safe for you? Retrieved from https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/aspirin/art-20047573
3. StatPearls. (2021, April 15). Aspirin. Treasure Island (FL): StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513275/