See the DrugPatentWatch profile for methotrexate

Combining methotrexate with herbal supplements can be risky and potentially harmful. Methotrexate is a powerful medication used to treat various conditions, including rheumatoid arthritis, psoriasis, and certain types of cancer. While herbal supplements may seem harmless, they can interact with methotrexate and alter its effectiveness or increase the risk of adverse effects.

Some herbal supplements, such as St. John's Wort, can reduce the effectiveness of methotrexate by increasing its metabolism and elimination from the body [1]. This may lead to reduced efficacy and increased risk of treatment failure. Additionally, certain herbal supplements like ginkgo biloba and ginseng may interact with methotrexate and increase the risk of bleeding, particularly in patients taking anticoagulant medications [2].

Furthermore, herbal supplements can also increase the risk of liver damage, which is a known side effect of methotrexate. For instance, the herb kava can cause liver damage and interact with methotrexate, potentially leading to liver toxicity [3].

It is essential to note that the quality and purity of herbal supplements can vary significantly, and some may contain contaminants or heavy metals that can exacerbate the risks associated with methotrexate use [4]. Therefore, it is crucial to consult with a healthcare provider before combining methotrexate with herbal supplements.

In conclusion, combining methotrexate with herbal supplements can be risky and potentially harmful. Patients taking methotrexate should consult with their healthcare provider before using any herbal supplements to ensure safe and effective treatment.

Sources:

[1] DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/patent/US-6-165-444>

[2] National Institutes of Health. (2020). Ginkgo biloba. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK92754/>

[3] European Medicines Agency. (2019). Kava. Retrieved from <https://www.ema.europa.eu/en/medicines/herbal/kava>

[4] World Health Organization. (2019). Herbal Medicines. Retrieved from <https://www.who.int/news-room/fact-sheets/detail/herbal-medicines>

Note: The sources listed above are cited in the response and provide additional information on the potential risks and interactions associated with combining methotrexate with herbal supplements.