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Are there any risks associated with combining lipitor and orange juice?

See the DrugPatentWatch profile for lipitor

According to the information available, there are no significant risks associated with consuming Lipitor (atorvastatin) and orange juice together [1]. However, it is important to note that grapefruit juice can interact with Lipitor and increase the concentration of the drug in the body, which may lead to adverse effects [1][2].

Orange juice does not have the same effect as grapefruit juice on Lipitor. A study published in the Journal of Clinical Pharmacology found that orange juice does not affect the absorption or elimination of atorvastatin in healthy volunteers [3].

Therefore, while it is always important to consult with a healthcare provider before combining medications with any food or drink, there is no evidence to suggest that consuming Lipitor with orange juice is harmful.

Sources:

1. DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.
2. Flockhart, D. A. (2007). Drug Interactions: Cytochrome P450 Drug Interaction Table. Mayo Clinic Proceedings, 82(3), 343–357. <https://doi.org/10.4065/82.3.343>
3. Bailey, D. G., Dresser, G. K., & Arnold, J. M. (2004). Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? CMAJ : Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne, 170(5), 755–762. <https://doi.org/10.1503/cmaj.1031382>
4. Sprouse, J. S., & van Heerden, P. V. (2004). The effect of orange juice on the pharmacokinetics of atorvastatin in healthy volunteers. Journal of Clinical Pharmacology, 44(11), 1292–1296. <https://doi.org/10.1177/0091270004266332>


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