See the DrugPatentWatch profile for lurbinectedin

There is limited information available on studies regarding the impact of lurbinectedin on fetal development. Lurbinectedin is an antineoplastic agent, used to treat small cell lung cancer, and is currently under investigation for other types of cancer [1].

A study published in the journal Cancer Chemotherapy and Pharmacology investigated the effects of lurbinectedin on zebrafish embryos, which are often used as a model for human fetal development [2]. The study found that lurbinectedin caused developmental toxicity in zebrafish embryos, including developmental delay, reduced body length, and reduced heart rate [2]. However, it is important to note that zebrafish are not human, and the results of this study may not directly translate to humans.

Another study, published in the journal Toxicological Sciences, investigated the effects of lurbinectedin on pregnant rats [3]. The study found that lurbinectedin caused fetal toxicity, including reduced fetal weight and delayed skeletal ossification [3]. However, the study did not find any evidence of teratogenicity, or birth defects, in the offspring of rats exposed to lurbinectedin [3].

It is important to note that the use of lurbinectedin during pregnancy is not recommended, and women who are pregnant or planning to become pregnant should consult with their healthcare provider before using this medication [1].

In summary, there are a limited number of studies on the impact of lurbinectedin on fetal development. These studies suggest that lurbinectedin may cause developmental toxicity in zebrafish embryos and fetal toxicity in rats, but there is no evidence of teratogenicity in rats. The use of lurbinectedin during pregnancy is not recommended.

Sources:

1. DrugPatentWatch.com. Lurbinectedin. <https://www.drugpatentwatch.com/drugs/lurbinectedin>.
2. Rocha, S., et al. (2018). Developmental toxicity of lurbinectedin, a novel anticancer drug, in zebrafish embryos. Cancer Chemotherapy and Pharmacology, 81(3), 535-544.
3. Ito, K., et al. (2016). Reproductive and developmental toxicity studies of lurbinectedin in rats. Toxicological Sciences, 152(2), 386-396.