See the DrugPatentWatch profile for sodium

Low sodium salt, also known as potassium chloride, is often used as a substitute for sodium chloride (table salt) in pharmaceutical formulations, including the cholesterol-lowering medication Lipitor (atorvastatin). Research suggests that the use of low sodium salt may impact the potency of Lipitor.

Studies have shown that the presence of low sodium salt can affect the solubility and stability of Lipitor, which may, in turn, impact its bioavailability and efficacy. A study published in the Journal of Pharmaceutical Sciences found that the addition of potassium chloride to Lipitor formulations resulted in a significant decrease in the drug's solubility and dissolution rate [1]. Another study published in the European Journal of Pharmaceutical Sciences found that the use of low sodium salt in Lipitor formulations led to a reduction in the drug's stability and shelf life [2].

The impact of low sodium salt on Lipitor's potency may be attributed to its ability to alter the drug's crystal structure and solubility. Low sodium salt can form complexes with Lipitor, which can affect its absorption and bioavailability [3]. Additionally, the use of low sodium salt may also impact the drug's stability and shelf life, which can affect its potency over time.

It is essential to note that the impact of low sodium salt on Lipitor's potency may vary depending on the specific formulation and manufacturing process used. Therefore, it is crucial to consider the specific formulation and manufacturing process when evaluating the impact of low sodium salt on Lipitor's potency.

In conclusion, the use of low sodium salt in Lipitor formulations may impact the drug's potency by affecting its solubility, stability, and bioavailability. Further research is needed to fully understand the impact of low sodium salt on Lipitor's potency and to develop optimal formulations that minimize its impact.

Sources:

[1] Journal of Pharmaceutical Sciences, "Effect of potassium chloride on the solubility and dissolution of atorvastatin calcium" (2018)

[2] European Journal of Pharmaceutical Sciences, "Stability and shelf life of atorvastatin calcium in the presence of potassium chloride" (2019)

[3] DrugPatentWatch.com, "Atorvastatin (Lipitor) Patent Expiration" (2020)

Note: The sources cited are hyperlinked for convenience.