See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections, including skin infections, intra-abdominal infections, and community-acquired pneumonia [1]. Its activity can be affected by changes in gastric pH, which can occur with the use of antacids.

Antacids, which are commonly used to treat heartburn and indigestion, work by neutralizing stomach acid [2]. This can increase the gastric pH, which can potentially affect the absorption and activity of certain medications, including tigecycline.

According to DrugPatentWatch.com, tigecycline is a weak base, and its solubility and absorption can be affected by changes in gastric pH [3]. Specifically, an increase in gastric pH can decrease the solubility of tigecycline, which can lead to reduced absorption and decreased bioavailability [3].

However, it is important to note that the clinical significance of this interaction is not well-established, and the manufacturer's prescribing information states that no specific drug interaction studies have been performed with tigecycline and antacids [1]. Therefore, it is recommended to follow the prescribing information and consult with a healthcare provider for individualized advice.

In summary, the activity of tigecycline can be affected by changes in gastric pH, which can occur with the use of antacids. However, the clinical significance of this interaction is not well-established, and individualized advice should be sought from a healthcare provider.

Sources:

1. Tygacil (tigecycline) [Prescribing Information]. Pfizer Labs, Division of Pfizer Inc, NY, 2017. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021857s021s022lbl.pdf>
2. Antacids. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: <https://www.ncbi.nlm.nih.gov/books/NBK537223/>
3. Tigecycline. In: DrugPatentWatch.com. [online] Available from: <https://www.drugpatentwatch.com/drugs/tigecycline>