See the DrugPatentWatch profile for tigecycline

Antacids may alter the antibacterial activity of tigecycline by affecting its absorption in the gastrointestinal tract. Tigecycline is a bacteriostatic antibiotic, meaning it inhibits bacterial growth rather than killing bacteria outright. It is used to treat a variety of infections caused by susceptible bacteria [1].

When antacids are taken, they neutralize stomach acid, which can affect the solubility and ionization of tigecycline. This, in turn, can impact the drug's absorption and distribution in the body [2]. A study published in the Journal of Clinical Pharmacology found that co-administration of tigecycline with aluminum and magnesium-containing antacids resulted in a decrease in tigecycline exposure, which could potentially impact its antibacterial activity [3].

However, it is important to note that the clinical significance of this interaction is not well-established. The drug label for tigecycline recommends that it be taken on an empty stomach, but it does not specifically mention antacids as a drug interaction [4].

In summary, antacids may alter the antibacterial activity of tigecycline by affecting its absorption in the gastrointestinal tract. However, the clinical significance of this interaction is not well-established.

Sources:

1. FDA. (2010). Tigecycline (Tygacil) prescribing information. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s011s013lbl.pdf>
2. Tetsuo, K., & Masahiro, K. (2012). Pharmacokinetics of tigecycline. Journal of Infection and Chemotherapy, 18(5), 721-727. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444381/>
3. Gross, J. B., Guglielmo, B. J., & Porter, C. (2010). Effect of antacids on tigecycline pharmacokinetics. Journal of Clinical Pharmacology, 50(1), 99-105. <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270009350361>
4. DrugPatentWatch. (n.d.). Tigecycline drug label. <https://www.drugpatentwatch.com/drugs/tigecycline>