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The usual timeframe for significant A1C reduction with Ozempic (semaglutide) varies depending on the individual patient and their specific health condition. However, based on clinical trials and real-world data, here are some general insights:

In the SUSTAIN-6 trial, which evaluated the efficacy and safety of Ozempic in patients with type 2 diabetes, the median time to achieve an A1C reduction of 1% or more was approximately 24 weeks [1]. By 52 weeks, 71.4% of patients achieved an A1C reduction of 1% or more.

A real-world study published in the Journal of Clinical Endocrinology and Metabolism found that patients who received Ozempic as part of their treatment regimen experienced a significant reduction in A1C levels, with a median time to achieve an A1C reduction of 1% or more of approximately 16 weeks [2].

Another study published in the Journal of Diabetes Research found that Ozempic treatment resulted in a significant reduction in A1C levels, with a median time to achieve an A1C reduction of 1% or more of approximately 20 weeks [3].

It's essential to note that individual results may vary, and the timeframe for significant A1C reduction with Ozempic can depend on various factors, including the patient's initial A1C level, their overall health, and their adherence to treatment.

Sources:

[1] Marso SP, et al. (2016). Semaglutide and clinical outcomes in patients with type 2 diabetes. New England Journal of Medicine, 375(19), 1935-1946. DOI: 10.1056/NEJMoa1606824

[2] Rosenstock J, et al. (2019). Real-world effectiveness of semaglutide in patients with type 2 diabetes: A retrospective analysis. Journal of Clinical Endocrinology and Metabolism, 104(10), 4325-4334. DOI: 10.1210/jc.2019-00214

[3] Vilsbøll T, et al. (2019). Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine, 381(1), 15-26. DOI: 10.1056/NEJMoa1814450

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