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When combining Advil (ibuprofen) and antidepressants, there are potential side effects that can occur. It is essential to be aware of these potential interactions, as both Advil and antidepressants are widely used and can be obtained over the counter or by prescription.

Advil, a non-steroidal anti-inflammatory drug (NSAID), can interact with certain antidepressants, leading to potential adverse effects. Specifically, Advil can interact with selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [1].

Combining Advil with SSRIs or SNRIs can increase the risk of developing serotonin syndrome, a potentially life-threatening condition [1]. Symptoms of serotonin syndrome include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, diarrhea, and fever [1].

Additionally, combining Advil with antidepressants can increase the risk of gastrointestinal bleeding [1]. This risk is higher in older adults and those with a history of ulcers or gastrointestinal bleeding [1].

It is crucial to consult a healthcare provider before combining Advil and antidepressants. A healthcare provider can evaluate the potential risks and benefits of combining these medications and provide guidance on managing potential side effects [1].

In summary, combining Advil and antidepressants can increase the risk of developing serotonin syndrome and gastrointestinal bleeding. Consulting a healthcare provider before combining these medications is essential.

Sources:

1. DrugPatentWatch.com. (n.d.). Advil and Antidepressants. Retrieved from <https://www.drugpatentwatch.com/drug-interactions/advil-and-antidepressants>