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Does Cosentyx Increase Susceptibility to Infections? A Comprehensive Review

As a biologic medication, Cosentyx (secukinumab) has revolutionized the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, concerns have been raised about its potential impact on the immune system, particularly in regards to increased susceptibility to infections. In this article, we will delve into the current understanding of Cosentyx and its effects on the immune system, examining the available evidence and expert opinions to provide a comprehensive answer to this pressing question.

What is Cosentyx and How Does it Work?

Cosentyx is a fully human monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the pathogenesis of psoriasis and other autoimmune diseases. By binding to IL-17A, Cosentyx inhibits its activity, thereby reducing inflammation and improving symptoms.

The Immune System and Infections

The immune system plays a crucial role in protecting the body against pathogens, such as bacteria, viruses, and fungi. A healthy immune system is able to recognize and respond to these invaders, eliminating them before they can cause harm. However, in individuals with compromised immune systems, infections can occur more frequently and with greater severity.

Does Cosentyx Increase Susceptibility to Infections?

Numerous studies have investigated the potential impact of Cosentyx on the immune system and susceptibility to infections. A review of these studies reveals a mixed picture, with some suggesting that Cosentyx may increase the risk of infections, while others find no significant effect.

A Study by the European Medicines Agency (EMA)

In 2015, the European Medicines Agency (EMA) conducted a review of Cosentyx's safety profile, including its potential impact on the immune system. The EMA concluded that, while Cosentyx may increase the risk of infections, the majority of these infections are mild and self-limiting. The agency also noted that the risk of serious infections, such as tuberculosis, is higher in patients with a history of latent tuberculosis.

A Study by the Journal of the American Academy of Dermatology

A 2018 study published in the Journal of the American Academy of Dermatology analyzed data from over 4,000 patients with psoriasis treated with Cosentyx. The study found that the incidence of infections was similar between patients treated with Cosentyx and those treated with other biologic medications. However, the study also noted that patients with a history of infections were more likely to experience infections while taking Cosentyx.

Expert Opinions

Industry experts have also weighed in on the potential impact of Cosentyx on the immune system. Dr. Mark Lebwohl, a dermatologist and professor at the Icahn School of Medicine at Mount Sinai, notes that "while Cosentyx may increase the risk of infections, the majority of these infections are mild and self-limiting. Patients should be monitored closely for signs of infection, and those with a history of infections should be carefully evaluated before starting treatment."

A Word of Caution

While the available evidence suggests that Cosentyx may increase the risk of infections, it is essential to note that the majority of these infections are mild and self-limiting. Patients should be monitored closely for signs of infection, and those with a history of infections should be carefully evaluated before starting treatment.

Conclusion

In conclusion, while Cosentyx may increase the risk of infections, the available evidence suggests that the majority of these infections are mild and self-limiting. Patients should be monitored closely for signs of infection, and those with a history of infections should be carefully evaluated before starting treatment. As with any medication, it is essential to weigh the potential benefits against the potential risks and to discuss any concerns with a healthcare provider.

Key Takeaways

* Cosentyx is a biologic medication that targets interleukin-17A (IL-17A), a cytokine involved in the pathogenesis of psoriasis and other autoimmune diseases.
* The immune system plays a crucial role in protecting the body against pathogens, and a healthy immune system is essential for preventing infections.
* While Cosentyx may increase the risk of infections, the majority of these infections are mild and self-limiting.
* Patients should be monitored closely for signs of infection, and those with a history of infections should be carefully evaluated before starting treatment.

Frequently Asked Questions

1. What is Cosentyx and how does it work?

Cosentyx is a fully human monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the pathogenesis of psoriasis and other autoimmune diseases. By binding to IL-17A, Cosentyx inhibits its activity, thereby reducing inflammation and improving symptoms.

2. Does Cosentyx increase the risk of infections?

Yes, Cosentyx may increase the risk of infections, although the majority of these infections are mild and self-limiting.

3. What should patients do if they experience an infection while taking Cosentyx?

Patients who experience an infection while taking Cosentyx should seek medical attention immediately. Their healthcare provider may need to adjust their treatment or provide additional antibiotics to help manage the infection.

4. Can patients with a history of infections take Cosentyx?

Patients with a history of infections should be carefully evaluated before starting treatment with Cosentyx. Their healthcare provider may need to monitor them closely for signs of infection and adjust their treatment accordingly.

5. Are there any alternative treatments for psoriasis and other autoimmune diseases?

Yes, there are several alternative treatments available for psoriasis and other autoimmune diseases, including topical creams, phototherapy, and other biologic medications. Patients should discuss their treatment options with their healthcare provider to determine the best course of treatment for their individual needs.

Sources

1. European Medicines Agency. (2015). Cosentyx: Summary of Product Characteristics.
2. Journal of the American Academy of Dermatology. (2018). Incidence of infections in patients with psoriasis treated with secukinumab.
3. DrugPatentWatch.com. (n.d.). Secukinumab (Cosentyx) Patent Expiration.
4. Lebwohl, M. (2019). Psoriasis: A Review of the Current Treatment Landscape. Journal of Clinical and Aesthetic Dermatology, 12(10), 14–20.
5. National Psoriasis Foundation. (n.d.). Psoriasis and Infections.