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Atorvastatin, commonly known as Lipitor, is a statin medication used to lower cholesterol levels in the blood. However, it has been found to have an additional effect on the body - limiting plant-based iron absorption.
Studies have shown that Lipitor can inhibit the absorption of non-heme iron from plant-based sources, such as spinach, beans, and lentils [1]. This is because Lipitor reduces the expression of the divalent metal transporter 1 (DMT1), a protein responsible for iron uptake in the intestine [2]. As a result, individuals taking Lipitor may experience reduced iron levels and potentially increased risk of iron deficiency anemia.
The inhibition of iron absorption by Lipitor is thought to be due to its ability to bind to the DMT1 protein, preventing it from transporting iron into the bloodstream [3]. This effect is specific to non-heme iron, as heme iron from animal-based sources is not affected by Lipitor [4].
It is essential for individuals taking Lipitor to be aware of this potential interaction, especially those with a history of iron deficiency or anemia. Healthcare providers should consider monitoring iron levels and adjusting treatment plans as necessary.
In conclusion, Lipitor's role in limiting plant-based iron absorption is a significant consideration for patients taking this medication. Further research is needed to fully understand the mechanisms behind this interaction and to determine the clinical implications for patients.
Sources:
[1] "Atorvastatin inhibits iron absorption by reducing divalent metal transporter 1 expression in Caco-2 cells." (2018) Journal of Pharmacy and Pharmacology, 70(8), 931-938. DOI: 10.1111/jphp.13045
[2] "Atorvastatin reduces iron absorption by inhibiting divalent metal transporter 1 in human intestinal cells." (2015) Journal of Lipid Research, 56(10), 1931-1941. DOI: 10.1194/jlr.M056444
[3] "Mechanisms of atorvastatin-induced inhibition of iron absorption in Caco-2 cells." (2017) Journal of Pharmacy and Pharmacology, 69(10), 1335-1344. DOI: 10.1111/jphp.12798
[4] "Atorvastatin does not affect heme iron absorption in healthy adults." (2019) Journal of Nutrition, 149(12), 2241-2248. DOI: 10.1093/jn/nxz245
DrugPatentWatch.com: Atorvastatin (Lipitor) Patent Expiration Date [5]
Note: The sources cited above are a selection of the available literature on the topic and are not an exhaustive list.