See the DrugPatentWatch profile for advil

Yes, long-term use of Advil (ibuprofen) can lead to serious side effects. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever. While generally safe for short-term use, long-term use can increase the risk of severe side effects, particularly gastrointestinal (GI) complications and cardiovascular issues [1].

Long-term Advil use can cause stomach ulcers, bleeding, and perforation in the GI tract. These complications can occur without noticeable symptoms and may lead to hospitalization or even death in severe cases [1][2].

Additionally, long-term NSAID use, including Advil, has been associated with an increased risk of cardiovascular events, such as heart attack and stroke [1]. This risk is generally higher in individuals with preexisting heart conditions or risk factors [1].

It is essential to consult a healthcare professional before starting or continuing long-term Advil use. They may recommend alternative treatments, such as acetaminophen or other pain management strategies, to minimize the risk of severe side effects [1].

Sources:

1. U.S. Food and Drug Administration. (2020, February 11). FDA adds boxed warning for non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs): risk of heart attack, stroke, and death. <https://www.fda.gov/drugs/drug-safety-and-availability/fda-adds-boxed-warning-non-aspirin-nonsteroidal-anti-inflammatory-drugs-nsaids-risk-heart-attack-stroke-and-death>
2. National Institute of Diabetes and Digestive and Kidney Diseases. (2016, September). Nonsteroidal Anti-inflammatory Drugs (NSAIDs). <https://www.niddk.nih.gov/health-information/illness-conditions/nonsteroidal-anti-inflammatory-drugs-nsaids>
3. DrugPatentWatch. (n.d.). Advil (ibuprofen) Patent Expiration & Generics. <https://www.drugpatentwatch.com/drugs/advil>