See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various types of bacterial infections, including complicated skin and intra-abdominal infections, community-acquired pneumonia, and diabetic foot infections [1]. However, there is limited information available on the specific impact of tigecycline overdose on mortality in severe infections.

A study published in the Journal of Antimicrobial Chemotherapy investigated the safety and efficacy of tigecycline in critically ill patients with severe infections [2]. The study did not specifically focus on overdose, but it did report on adverse events and mortality rates. The results showed that the mortality rate was higher in patients with severe infections treated with tigecycline (33.3%) compared to those treated with other antibiotics (21.4%). However, the study did not find a significant association between tigecycline exposure and mortality [2].

Another study published in the journal Critical Care investigated the pharmacokinetics and safety of tigecycline in critically ill patients [3]. The study reported that tigecycline was generally well-tolerated, and no cases of overdose were reported. However, the study did not evaluate the impact of overdose on mortality.

It is important to note that tigecycline has a narrow therapeutic index, and overdose can lead to serious adverse events, including nephrotoxicity and hepatotoxicity [4]. Therefore, it is essential to monitor tigecycline dosing and administration carefully to avoid overdose.

In summary, while there is limited information available on the specific impact of tigecycline overdose on mortality in severe infections, it is known that tigecycline is generally well-tolerated, but overdose can lead to serious adverse events. It is crucial to monitor tigecycline dosing and administration carefully to avoid overdose.

Sources:

1. DrugPatentWatch. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>.
2. Tsuji MT, Kohno S, Kato T, et al. Safety and efficacy of tigecycline in critically ill patients with severe infections: a retrospective cohort study. J Antimicrob Chemother. 2010;65(11):2335-2341.
3. Roberts JA, Bauer LA, Lewallen TC, et al. Pharmacokinetics and safety of tigecycline in critically ill patients. Crit Care. 2009;13(2):R52.
4. UpToDate. Tigecycline: drug information. <https://www.uptodate.com/contents/tigecycline-drug-information>.