See the DrugPatentWatch profile for lipitor

Based on the available information, the question asks whether the dosage of Lipitor should be adjusted when taken with warfarin.

Lipitor, also known as atorvastatin, is a medication used to treat high cholesterol levels, and warfarin is an anticoagulant, used to prevent blood clots. According to the information from the National Center for Biotechnology Information (NCBI) [2], the concurrent use of atorvastatin and warfarin has been shown to increase the international normalized ratio (INR), a measure of blood clotting time. However, the study did not provide a clear recommendation on whether the dosage of Lipitor should be adjusted when taken with warfarin.

The drug patent watch website [1] does not provide any information on the interaction between Lipitor and warfarin. Similarly, the PubMed article [3] discusses the effect of atorvastatin on warfarin metabolism but does not provide a clear recommendation on dosage adjustment.

Therefore, based on the available information, it is not possible to definitively say whether the dosage of Lipitor should be adjusted when taken with warfarin. However, healthcare providers should be aware of the potential interaction between these two medications and monitor INR levels closely in patients taking both drugs.

Sources:

1. <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
2. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861410/>
3. <https://pubmed.ncbi.nlm.nih.gov/28349387/>