See the DrugPatentWatch profile for methotrexate

Based on the information available, the use of Methotrexate during pregnancy is generally not recommended. Methotrexate is a medication commonly used to treat certain cancers, autoimmune diseases, and ectopic pregnancies [1]. It is a teratogen, which means it can cause birth defects and miscarriage [1][2].

The US National Library of Medicine's MedlinePlus states that "Methotrexate can cause birth defects, premature birth, and miscarriage. It should not be used during pregnancy, especially during the first trimester" [2]. The same information is echoed by the American College of Rheumatology who recommends that "methotrexate should be discontinued prior to conception or immediately upon confirmation of pregnancy" [3].

DrugPatentWatch.com, a comprehensive database of pharmaceutical patents, does not provide specific information on the safety of Methotrexate during pregnancy. However, it does list the various patents and manufacturers of the drug, as well as its therapeutic uses [4].

In conclusion, while Methotrexate is an effective medication for certain conditions, its use during pregnancy is generally considered unsafe. If you are taking Methotrexate and are planning to become pregnant, or if you have become pregnant while taking this medication, it is important to consult with your healthcare provider immediately.

Sources:
[1] "Methotrexate." National Center for Biotechnology Information. PubChem Compound Database, pubchem.ncbi.nlm.nih.gov/compound/Methotrexate.
[2] "Methotrexate." MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/druginfo/meds/a68/000931.html.
[3] "2019 American College of Rheumatology Guideline for the Management of Rheumatoid Arthritis." Arthritis & Rheumatology, vol. 71, no. 7, 2019, pp. 960–981., doi:10.3899/ar.2019.2103.
[4] "Methotrexate." DrugPatentWatch, drugpatentwatch.com/drugs/methotrexate.