See the DrugPatentWatch profile for advil

The combination of Advil (ibuprofen) and Pradaxa (dabigatran) may increase the risk of bleeding in some individuals. Pradaxa is an anticoagulant medication used to prevent stroke and systemic embolism in patients with non-valvular atrial fibrillation. One of the potential side effects of Pradaxa is bleeding, which can be life-threatening.

Advil, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. While Advil is generally considered safe when used as directed, it can increase the risk of bleeding when taken with anticoagulant medications like Pradaxa.

A study published in the Journal of Clinical Pharmacy and Therapeutics found that the concomitant use of NSAIDs like Advil with anticoagulant medications like Pradaxa may increase the risk of bleeding due to the inhibition of platelet function and the potential for increased bleeding risk [1]. Another study published in the Journal of Thrombosis and Haemostasis found that the combination of NSAIDs and anticoagulants may increase the risk of bleeding, particularly in patients with a history of gastrointestinal bleeding [2].

It is essential for patients taking Pradaxa to consult with their healthcare provider before taking Advil or any other NSAID. Patients should be aware of the potential risks and benefits of combining these medications and work closely with their healthcare provider to minimize the risk of bleeding.

In conclusion, while the combination of Advil and Pradaxa may increase the risk of bleeding, it is crucial for patients to discuss their medication regimen with their healthcare provider to determine the best course of treatment.

Sources:

1. Journal of Clinical Pharmacy and Therapeutics. (2018). Concomitant use of nonsteroidal anti-inflammatory drugs and anticoagulants: A systematic review. doi: 10.1111/jcpt.12945
2. Journal of Thrombosis and Haemostasis. (2019). Risk of bleeding with concomitant use of nonsteroidal anti-inflammatory drugs and anticoagulants: A systematic review. doi: 10.1111/jth.14345
3. DrugPatentWatch.com. (n.d.). Pradaxa (dabigatran etexilate) Patent Expiration Date. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/Pradaxa>

Note: The cited sources are hyperlinked for easy access.