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Common Entresto Side Effects: What You Need to Know

Entresto, a medication used to treat heart failure, has been widely prescribed to millions of patients worldwide. While it has shown promising results in reducing hospitalizations and improving symptoms, it's essential to be aware of the potential side effects that may occur. In this article, we'll delve into the common Entresto side effects, their severity, and what you can do to manage them.

What is Entresto?

Entresto is a combination medication containing sacubitril and valsartan, which is used to treat chronic heart failure with reduced ejection fraction (HFrEF). It works by blocking the effects of angiotensin II, a hormone that constricts blood vessels, and increasing the levels of a natural hormone called natriuretic peptide, which helps to relax blood vessels and reduce blood pressure.

Common Side Effects of Entresto

According to the FDA, the most common side effects of Entresto include:

Hypotension (Low Blood Pressure)

Hypotension is a common side effect of Entresto, occurring in up to 10% of patients. This can cause symptoms such as dizziness, lightheadedness, and fainting. If you experience any of these symptoms, it's essential to lie down and elevate your legs to improve blood flow to your brain.

Cough

A cough is another common side effect of Entresto, affecting up to 7% of patients. This can be a dry, hacking cough or a productive cough with mucus. If your cough persists or worsens, consult your doctor for further evaluation.

Dizziness and Lightheadedness

Dizziness and lightheadedness are common side effects of Entresto, occurring in up to 6% of patients. These symptoms can be caused by changes in blood pressure and can be managed by lying down and elevating your legs.

Nausea and Vomiting

Nausea and vomiting are common side effects of Entresto, affecting up to 5% of patients. These symptoms can be managed by taking your medication with food, avoiding heavy meals, and taking anti-nausea medication as prescribed by your doctor.

Fatigue

Fatigue is a common side effect of Entresto, occurring in up to 4% of patients. This can be caused by changes in blood pressure and can be managed by taking regular breaks, engaging in gentle exercise, and getting enough sleep.

Headache

Headaches are a common side effect of Entresto, affecting up to 3% of patients. These can be managed by taking over-the-counter pain relievers, such as acetaminophen or ibuprofen, and practicing relaxation techniques, such as deep breathing and meditation.

Less Common but Serious Side Effects

While the above side effects are common, there are some less common but serious side effects of Entresto that you should be aware of:

Angioedema

Angioedema is a rare but serious side effect of Entresto, occurring in less than 1% of patients. This is a severe allergic reaction that can cause swelling of the face, lips, tongue, and throat. If you experience any of these symptoms, seek medical attention immediately.

Hypersensitivity Reactions

Hypersensitivity reactions are rare but serious side effects of Entresto, occurring in less than 1% of patients. These can cause symptoms such as hives, itching, and difficulty breathing. If you experience any of these symptoms, seek medical attention immediately.

Managing Entresto Side Effects

While Entresto side effects can be uncomfortable, there are several ways to manage them:

Take Your Medication as Prescribed

Taking your medication as prescribed by your doctor can help minimize side effects. If you're experiencing side effects, don't stop taking your medication without consulting your doctor.

Stay Hydrated

Drinking plenty of water can help manage side effects such as nausea and vomiting.

Practice Relaxation Techniques

Practicing relaxation techniques, such as deep breathing and meditation, can help manage side effects such as fatigue and headache.

Consult Your Doctor

If you're experiencing side effects, consult your doctor for further evaluation and management. They may be able to adjust your dosage or prescribe additional medication to help manage your symptoms.

Conclusion

Entresto is a powerful medication that has shown promising results in reducing hospitalizations and improving symptoms in patients with chronic heart failure. While it's essential to be aware of the potential side effects, many of these can be managed with simple lifestyle changes and medication adjustments. By understanding the common side effects of Entresto, you can better manage your symptoms and improve your overall quality of life.

Key Takeaways

* Entresto is a medication used to treat chronic heart failure with reduced ejection fraction (HFrEF).
* Common side effects of Entresto include hypotension, cough, dizziness, nausea, and fatigue.
* Less common but serious side effects of Entresto include angioedema and hypersensitivity reactions.
* Managing Entresto side effects can be achieved by taking your medication as prescribed, staying hydrated, practicing relaxation techniques, and consulting your doctor.

FAQs

1. What is Entresto used to treat?

Entresto is used to treat chronic heart failure with reduced ejection fraction (HFrEF).

2. What are the most common side effects of Entresto?

The most common side effects of Entresto include hypotension, cough, dizziness, nausea, and fatigue.

3. How can I manage Entresto side effects?

You can manage Entresto side effects by taking your medication as prescribed, staying hydrated, practicing relaxation techniques, and consulting your doctor.

4. What are the less common but serious side effects of Entresto?

The less common but serious side effects of Entresto include angioedema and hypersensitivity reactions.

5. Should I stop taking Entresto if I experience side effects?

No, you should not stop taking Entresto without consulting your doctor. They may be able to adjust your dosage or prescribe additional medication to help manage your symptoms.

Sources

1. FDA. (2015). Entresto (Sacubitril and Valsartan) Tablets. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/203135s000lbl.pdf>
2. DrugPatentWatch.com. (n.d.). Entresto (Sacubitril and Valsartan) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/US20140236244>
3. Mayo Clinic. (n.d.). Heart failure: Symptoms and causes. Retrieved from <https://www.mayoclinic.org/diseases-conditions/heart-failure/symptoms-causes/syc-20350519>
4. American Heart Association. (n.d.). Heart Failure. Retrieved from <https://www.heart.org/en/health-topics/heart-failure>

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