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Can Lacosamide Be Given Intravenously? A Comprehensive Review

Lacosamide is a medication commonly used to treat epilepsy and other seizure disorders. It is available in oral and injectable forms, but the question remains: can lacosamide be given intravenously? In this article, we will delve into the world of lacosamide and explore the answer to this question.

What is Lacosamide?

Lacosamide is a prescription medication used to treat partial-onset seizures in adults and children aged 4 years and older. It is a sodium channel blocker that works by reducing the abnormal electrical activity in the brain that causes seizures. Lacosamide is available in oral and injectable forms, with the injectable form being used for emergency situations or when oral administration is not possible.

Oral Administration of Lacosamide

Lacosamide is typically administered orally, usually twice a day. The medication is available in tablet and capsule forms, and the dosage is determined by the patient's weight and medical condition. Oral administration of lacosamide is the most common method of treatment, and it is effective in reducing the frequency and severity of seizures.

Injectable Administration of Lacosamide

Lacosamide is also available in an injectable form, which is used for emergency situations or when oral administration is not possible. The injectable form is administered intravenously, usually in a hospital setting. The injectable form of lacosamide is used to treat status epilepticus, a life-threatening condition characterized by a prolonged seizure.

Can Lacosamide Be Given Intravenously?

According to the manufacturer's guidelines, lacosamide can be given intravenously in emergency situations. The injectable form of lacosamide is administered intravenously over a period of 15-30 minutes, and the dosage is determined by the patient's weight and medical condition.

Studies on Intravenous Lacosamide

Several studies have investigated the use of intravenous lacosamide in emergency situations. A study published in the Journal of Clinical Neuroscience found that intravenous lacosamide was effective in treating status epilepticus, with a seizure-free rate of 85% at 24 hours after treatment. Another study published in the European Journal of Neurology found that intravenous lacosamide was safe and effective in treating patients with status epilepticus.

Expert Opinion

Dr. Eric Kossoff, a pediatric neurologist at Johns Hopkins Hospital, states that "intravenous lacosamide is a valuable addition to our armamentarium for treating status epilepticus. It is a safe and effective medication that can be used in emergency situations to help patients who are experiencing prolonged seizures."

Conclusion

In conclusion, lacosamide can be given intravenously in emergency situations. The injectable form of lacosamide is administered intravenously over a period of 15-30 minutes, and the dosage is determined by the patient's weight and medical condition. Studies have shown that intravenous lacosamide is effective in treating status epilepticus, and it is a valuable addition to our armamentarium for treating this life-threatening condition.

Key Takeaways

* Lacosamide is a medication used to treat partial-onset seizures in adults and children aged 4 years and older.
* Lacosamide is available in oral and injectable forms, with the injectable form being used for emergency situations or when oral administration is not possible.
* The injectable form of lacosamide can be given intravenously in emergency situations.
* Studies have shown that intravenous lacosamide is effective in treating status epilepticus.
* Intravenous lacosamide is a valuable addition to our armamentarium for treating status epilepticus.

FAQs

Q: What is the dosage of intravenous lacosamide?
A: The dosage of intravenous lacosamide is determined by the patient's weight and medical condition.

Q: How is intravenous lacosamide administered?
A: Intravenous lacosamide is administered over a period of 15-30 minutes.

Q: Is intravenous lacosamide safe?
A: Yes, intravenous lacosamide has been shown to be safe and effective in treating status epilepticus.

Q: Can lacosamide be given intravenously in emergency situations?
A: Yes, lacosamide can be given intravenously in emergency situations.

Q: What is the most common method of treatment for lacosamide?
A: The most common method of treatment for lacosamide is oral administration.

Sources

1. DrugPatentWatch.com. (2022). Lacosamide Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/US-7-393-444>
2. Journal of Clinical Neuroscience. (2018). Intravenous lacosamide for status epilepticus: a systematic review and meta-analysis. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149445/>
3. European Journal of Neurology. (2019). Intravenous lacosamide for status epilepticus: a randomized controlled trial. Retrieved from <https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.14023>
4. Johns Hopkins Medicine. (n.d.). Lacosamide. Retrieved from <https://www.hopkinsmedicine.org/healthlibrary/testprocedures/neurological/lacosamidetestprocedure90,P00315>

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