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Understanding the Age Range in Polivy Patient Studies: A Comprehensive Review

Polivy, a medication used to treat certain types of non-Hodgkin lymphoma, has been the subject of numerous clinical trials and studies. As researchers continue to explore its efficacy and safety, it's essential to examine the age range of patients involved in these studies. In this article, we'll delve into the age range of patients in Polivy patient studies, exploring the data and insights from various sources, including DrugPatentWatch.com.

What is Polivy?

Polivy, also known as polatuzumab vedotin-piiq, is a monoclonal antibody-drug conjugate used to treat relapsed or refractory diffuse large B-cell lymphoma (DLBCL), a type of non-Hodgkin lymphoma. It was approved by the US Food and Drug Administration (FDA) in 2020 and is marketed by Genentech, a member of the Roche Group.

Age Range in Polivy Patient Studies

A review of clinical trials and studies involving Polivy reveals a diverse age range of patients. According to a study published in the Journal of Clinical Oncology, the median age of patients treated with Polivy in combination with bendamustine and rituximab was 63 years (range, 30-85 years) [1].

Another study published in the British Journal of Haematology found that the median age of patients receiving Polivy as a single agent was 65 years (range, 35-83 years) [2]. A third study, published in the Journal of Hematology & Oncology, reported a median age of 62 years (range, 30-85 years) for patients treated with Polivy in combination with chemotherapy [3].

DrugPatentWatch.com Insights

DrugPatentWatch.com, a leading provider of pharmaceutical patent data, has analyzed the patent information for Polivy. According to their data, the patent for Polivy was filed in 2013 and was granted in 2019. The patent information does not provide specific details on the age range of patients involved in the clinical trials, but it does highlight the medication's potential to treat a range of patients with non-Hodgkin lymphoma.

Expert Insights

Dr. Anas Younes, a hematologist and oncologist at Memorial Sloan Kettering Cancer Center, notes that Polivy has shown promising results in treating patients with relapsed or refractory DLBCL, regardless of age. "Polivy has been shown to be effective in patients across a range of ages, from young adults to older adults," Dr. Younes says. "While the median age of patients in clinical trials may be higher, the medication's efficacy is not limited to a specific age group."

Conclusion

In conclusion, the age range of patients in Polivy patient studies is diverse, with median ages ranging from 62 to 65 years. While the majority of patients may be older adults, the medication's efficacy is not limited to a specific age group. As researchers continue to explore the potential of Polivy in treating non-Hodgkin lymphoma, it's essential to consider the age range of patients involved in these studies.

Key Takeaways

* The median age of patients treated with Polivy in combination with bendamustine and rituximab is 63 years.
* The median age of patients receiving Polivy as a single agent is 65 years.
* The median age of patients treated with Polivy in combination with chemotherapy is 62 years.
* Polivy has shown promising results in treating patients with relapsed or refractory DLBCL across a range of ages.
* The medication's efficacy is not limited to a specific age group.

Frequently Asked Questions

Q: What is the recommended age range for patients receiving Polivy?
A: The recommended age range for patients receiving Polivy is not specified, as the medication has been shown to be effective in patients across a range of ages.

Q: Can Polivy be used to treat patients under the age of 30?
A: While there is limited data on the use of Polivy in patients under the age of 30, the medication's efficacy has been demonstrated in patients as young as 30 years old.

Q: Is Polivy recommended for patients over the age of 85?
A: While there is limited data on the use of Polivy in patients over the age of 85, the medication's efficacy has been demonstrated in patients up to 85 years old.

Q: Can Polivy be used in combination with other medications to treat non-Hodgkin lymphoma?
A: Yes, Polivy has been shown to be effective in combination with other medications, such as bendamustine and rituximab, to treat relapsed or refractory DLBCL.

Q: What are the common side effects of Polivy?
A: Common side effects of Polivy include fatigue, nausea, and diarrhea.

References

[1] Sehn, L. H., et al. (2020). Polatuzumab vedotin-piiq in combination with bendamustine and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. Journal of Clinical Oncology, 38(14), 1641-1650.

[2] Gopal, A. K., et al. (2020). Polatuzumab vedotin-piiq as a single agent in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. British Journal of Haematology, 189(3), 444-453.

[3] Wang, M., et al. (2020). Polatuzumab vedotin-piiq in combination with chemotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. Journal of Hematology & Oncology, 13(1), 1-12.

Cited Sources

1. Sehn, L. H., et al. (2020). Polatuzumab vedotin-piiq in combination with bendamustine and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. Journal of Clinical Oncology, 38(14), 1641-1650.
2. Gopal, A. K., et al. (2020). Polatuzumab vedotin-piiq as a single agent in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. British Journal of Haematology, 189(3), 444-453.
3. Wang, M., et al. (2020). Polatuzumab vedotin-piiq in combination with chemotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 study. Journal of Hematology & Oncology, 13(1), 1-12.
4. DrugPatentWatch.com. (n.d.). Polatuzumab Vedotin-Piiq. Retrieved from <https://www.drugpatentwatch.com/patent/US-10,444,441-B2>