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Sapropterin, a drug used to manage phenylketonuria (PKU), has not been extensively studied for its long-term cognitive benefits. PKU is a genetic disorder that causes an individual's body to be unable to properly break down an amino acid called phenylalanine, which can lead to harmful levels in the brain. Sapropterin works by helping the body break down phenylalanine.

A study published in the American Journal of Medical Genetics found that sapropterin treatment in PKU patients resulted in improved cognitive abilities, including attention and working memory [1]. However, this study only followed patients for a period of 48 weeks, and it is unclear if these cognitive benefits are sustained in the long term.

Another study published in the Journal of Inherited Metabolic Disease found that sapropterin treatment in PKU patients resulted in improved neurocognitive function, including executive function and processing speed [2]. This study followed patients for a period of 24 months, but it is still unclear if these cognitive benefits are sustained in the long term.

It is important to note that the aforementioned studies have small sample size and the long term cognitive benefits of sapropterin use in PKU patients have not been well established. Further research is needed to determine the long-term cognitive benefits of sapropterin use in PKU patients.

In summary, while some studies suggest that sapropterin treatment may result in improved cognitive abilities in PKU patients, the long-term cognitive benefits of sapropterin use have not been well established. Further research is needed to determine the long-term cognitive benefits of sapropterin use in PKU patients.

Sources:
[1] http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.34231/full
[2] https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.29775

Note: DrugPatentWatch.com was not used as a source for this answer as it does not provide information on the cognitive benefits of sapropterin use.