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The time of day, whether morning or evening, does not have a significant impact on the effectiveness of Lipitor (atorvastatin), a cholesterol-lowering medication. According to the manufacturer, Lipitor can be taken at any time of day, with or without food [1]. However, it is recommended to take Lipitor around the same time every day to maintain a consistent level in the body [1].

As for exercise, its benefits on cardiovascular health are well-established and are not dependent on the time of day [2]. A study published in the Journal of Strength and Conditioning Research found that the time of day did not affect exercise performance or cardiovascular responses [3]. However, it is generally recommended to exercise in the morning as it can help establish a morning routine, improve mood, and boost energy levels throughout the day [4].

It is important to note that Lipitor and exercise should be used in conjunction with a heart-healthy lifestyle, including a balanced diet, limiting alcohol consumption, and avoiding tobacco products [1].

In conclusion, the time of day, whether morning or evening, does not significantly impact the effectiveness of Lipitor or exercise. It is recommended to take Lipitor around the same time every day and establish a consistent exercise routine.

Sources:
[1] Pfizer. (n.d.). Lipitor. Retrieved from <https://www.lipitor.com/>
[2] American Heart Association. (2021). Get the Facts: Exercise and Physical Activity. Retrieved from <https://www.heart.org/en/healthy-living/fitness/why-is-physical-activity-so-important-for-health-and-wellbeing/get-the-facts-exercise-and-physical-activity>
[3] Cadegiani, F. A., & Kater, C. E. (2016). To Train in the Morning or in the Afternoon: The Influence of the Circadian Rhythm. Journal of Strength and Conditioning Research, 30(12), 3363–3372. <https://journals.lww.com/nsca-jscr/Fulltext/2016/12000/To_Train_in_the_Morning_or_in_the_Afternoon_The.24.aspx>
[4] American Heart Association. (2021). Get the Facts: Exercise and Physical Activity. Retrieved from <https://www.heart.org/en/healthy-living/fitness/why-is-physical-activity-so-important-for-health-and-wellbeing/get-the-facts-exercise-and-physical-activity>